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Merck

HNMT

histamine N-methyltransferase

Synonyms:
HMT, HNMT-S1, HNMT-S2
Species:
Human HNMT (3176), Mouse Hnmt (140483), Rat Hnmt (81676), chicken HNMT (424298), Zebrafish hnmt (445242), domestic cat HNMT (101093704), dog HNMT (476133), sheep HNMT (641310), cow HNMT (613413), domestic guinea pig Hnmt (100135537)
UniProtKB ID:
P50135, B2R9J3, Q546Z6, Q7Z7I2, Q8IU56, Q8WW98, Q9BRW6
Gene ID:
  • Human(3176) Summary: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(140483) histamine N-methyltransferase
  • Rat(81676) histamine N-methyltransferase
  • chicken(424298) histamine N-methyltransferase
  • Zebrafish(445242) histamine N-methyltransferase
  • domestic cat(101093704) histamine N-methyltransferase
  • dog(476133) histamine N-methyltransferase
  • sheep(641310) histamine N-methyltransferase
  • cow(613413) histamine N-methyltransferase
  • domestic guinea pig(100135537) histamine N-methyltransferase
  • sheep(101102876) histamine N-methyltransferase

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1410643
Anti-HNMT antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
HPA035481
Anti-HNMT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
HPA073754
Anti-HNMT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
western blot
HPA035480
Anti-HNMT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
EHU135431
MISSION® esiRNA, targeting human HNMT (3),
Species
human
EHU092321
MISSION® esiRNA, targeting human HNMT (1),
Species
human
EHU099901
MISSION® esiRNA, targeting human HNMT (2),
Species
human