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Merck

HFE

hemochromatosis

Synonyms:
HFE1, HH, HLA-H, MVCD7, TFQTL2
Species:
UniProtKB ID:
Gene ID:
  • Human(3077) Summary: The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
  • Mouse(15216) hemochromatosis
  • Rat(29199) hemochromatosis
  • naked mole-rat(101705145) hemochromatosis
  • dog(100688951) hemochromatosis
  • domestic cat(101084960) hemochromatosis
  • sheep(101105539) hemochromatosis
  • cow(497622) hemochromatosis

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-HFE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Monoclonal Anti-HFE antibody produced in mouse, clone 1G12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Anti-HFE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human HFE (1),
Species
human
MISSION® esiRNA, targeting mouse Hfe,
Species
mouse
MISSION® esiRNA, targeting human HFE (2),
Species
human