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Merck

DAZ1

deleted in azoospermia 1

Synonyms:
DAZ, SPGY
Species:
Human DAZ1 (1617)
UniProtKB ID:
Q9NQZ3, Q9NQZ4
Gene ID:
  • Human(1617) Summary: This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains. [provided by RefSeq, Jul 2008]

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Antibodies

Product Number
Description
Species Reactivity
Application
WH0001617M1
Monoclonal Anti-DAZ1 antibody produced in mouse, clone 3G10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB1400070
Monoclonal Anti-DAZ1 antibody produced in mouse, clone 3A4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
SAB1408932
Monoclonal Anti-DAZ1 antibody produced in mouse, clone 4F3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
SAB1403722
Monoclonal Anti-DAZ1 antibody produced in mouse, clone 3E3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
ABE374
Anti-DAZ Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
bovine, chimpanzee, equine, horse, human, mouse, pig, porcine, rat, rhesus macaque
Application
immunohistochemistry
western blot