CLDN16
claudin 16
Synonyms:
HOMG3, PCLN1
Species:
Human CLDN16 (10686), Mouse Cldn16 (114141), Rat Cldn16 (155268), chicken CLDN16 (429147), domestic cat CLDN16 (101094369), dog CLDN16 (608218), sheep CLDN16 (101105382), cow CLDN16 (282184), naked mole-rat Cldn16 (101708685), domestic guinea pig Cldn16 (100713868)
UniProtKB ID:
Gene ID:
- Human(10686) Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010]
- Mouse(114141) claudin 16
- Rat(155268) claudin 16
- chicken(429147) claudin 16
- domestic cat(101094369) claudin 16
- dog(608218) claudin 16
- sheep(101105382) claudin 16
- cow(282184) claudin 16
- naked mole-rat(101708685) claudin 16
- domestic guinea pig(100713868) claudin 16
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Claudin-16, from rabbit, purified by affinity chromatography,
Species Reactivity
canine, human
Application
immunocytochemistry
immunofluorescence
immunofluorescence
Monoclonal Anti-CLDN16, (N-terminal) antibody produced in mouse, clone 1F2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-CLDN16 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry