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  • Novel mutual pro-drugs of 2',3'-dideoxyinosine with 3-octadecyloxy-propane-1,2-diol by straightforward enzymatic regioselective synthesis in acetone.

Novel mutual pro-drugs of 2',3'-dideoxyinosine with 3-octadecyloxy-propane-1,2-diol by straightforward enzymatic regioselective synthesis in acetone.

Biotechnology letters (2005-02-11)
Xiao-Feng Sun, Qi Wu, Na Wang, Ying Cai, Xian-Fu Lin
ZUSAMMENFASSUNG

Novel mutual pro-drugs in which 2',3'-dideoxyinosine anti-HIV (human immunodeficiency virus) drug and 3-octadecyloxy-propane-1,2-diol anti-inflammatory drug were attached to the same molecule via different biodegradable linkages, were synthesized through two-step enzymatic transesterification by a commercial lipase in acetone.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Batylalkohol, 99%