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Synthesis of the sialidase inhibitor siastatin B.

Organic letters (2000-12-12)
S Knapp, D Zhao
ZUSAMMENFASSUNG

[structure] The resolved piperidinecarboxylate (R)-7 was converted to siastatin B (1) by an efficient and stereoselective sequence that includes a bromo-beta-lactonization and an N-acyliminium azidation. Two analogues (3 and 4) of siastatin were also prepared.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Siastatin B, lyophilized powder, from microbial