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  • [The use of genetic angiogenesis inductors in surgical treatment of chronic lower limb ischemia].

[The use of genetic angiogenesis inductors in surgical treatment of chronic lower limb ischemia].

Khirurgiia (2013-03-19)
A V Gavrilenko, D A Voronov, N P Bochkov
ZUSAMMENFASSUNG

The efficacy and safety of gene-engineering recombinant constructions with endothelial growth factor gene and angiogenin for the treatment of the chronic lower limb ischemia were studied. 134 patients were included in prospective controlled study. The main group, who received both traditional treatment and genetic therapy, consisted of 74 patients. The rest 60 patients were included into the control group. Of 74 patients from the main group, genetic therapy was used together with conservative means in 39 patients and with reconstructive vascular operations in 35 patients. The gene-engineering angiogenesis stimulation therapy proved to be effective and safe. The combination of angiogenesis genetic stimulation with reconstructive vascular surgery demonstrated significantly better results, then monotherapy.

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Sigma-Aldrich
Ribonuklease A aus Rinderpankreas, Type I-A, powder, ≥60% RNase A basis (SDS-PAGE), ≥50 Kunitz units/mg protein
Sigma-Aldrich
Ribonuklease A aus Rinderpankreas, for molecular biology, ≥70 Kunitz units/mg protein, lyophilized
Sigma-Aldrich
Ribonuklease A aus Rinderpankreas, Type III-A, ≥85% RNase A basis (SDS-PAGE), 85-140 Kunitz units/mg protein
Sigma-Aldrich
Ribonuklease A aus Rinderpankreas, (Solution of 50% glycerol, 10mM Tris-HCL pH 8.0)
Sigma-Aldrich
Ribonuklease A aus Rinderpankreas, Type I-AS, 50-100 Kunitz units/mg protein
Sigma-Aldrich
Ribonuklease A aus Rinderpankreas, Type XII-A, ≥90% (SDS-PAGE), 75-125 Kunitz units/mg protein
Sigma-Aldrich
Ribonuklease A aus Rinderpankreas, Type II-A, ≥60% (SDS-PAGE), >= 60 Kunitz units/mg protein
Sigma-Aldrich
Ribonuklease B aus Rinderpankreas, BioReagent, ≥50 Kunitz units/mg protein, ≥80% (SDS-PAGE)
Sigma-Aldrich
Ribonuklease A aus Rinderpankreas, Type X-A, ≥90% (SDS-PAGE), ≥70 Kunitz units/mg protein
Sigma-Aldrich
Ribonuclease A-agarose, ammonium sulfate suspension, 400-1,000 units/g agarose (One ml gel will yield 12-30 units)