SRP6508
Haptoglobin (Phenotype 2-2) from human plasma
≥95% (SDS-PAGE)
Synonym(e):
Hp 2-2
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About This Item
UNSPSC-Code:
12352202
NACRES:
NA.32
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Allgemeine Beschreibung
Haptoglobin(Hp) is an acute-phase antioxidant, found abundantly in the plasma , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2. The HP gene is mapped on the human chromosome at16q22.2.
Anwendung
Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells. It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.
Biochem./physiol. Wirkung
Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage. Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1. Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy. It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes. Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.
Physikalische Form
Lyophilized as a salt-free solid.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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The Haptoglobin 2-2 Phenotype Affects Serum Markers of Iron Status in Healthy Males
Michel R L, et al.
Clinical Chemistry, 46, 1619?1625-1619?1625 (2000)
The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness
Rinkoo D, et al.
Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease, 13(5), 373?376-373?376 (2016)
Seasonal Childhood Anaemia in West Africa Is Associated with the Haptoglobin 2-2 Genotype
Atkinson S, et al.
PLoS Medicine, 3(5), e172-e172 (2006)
Trans-ethnic predicted expression genome-wide association analysis identifies a gene for estrogen receptor-negative breast cancer
Guimin G, et al.
PLoS Genetics (2017)
Haptoglobin 2-2 Genotype is Not Associated With Cardiovascular Risk in Subjects With Elevated Glycohemoglobin?Results From the Bruneck Study
Raimund P, et al.
Journal of the American Heart Association (2014)
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