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SRP2075

Sigma-Aldrich

SRC1, FLAG tagged, TEV site human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym(e):

F-SRC-1, KAT13A, MGC129719, MGC129720, RIP160, SRC1, bHLHe42, bHLHe74

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About This Item

UNSPSC-Code:
12352200
NACRES:
NA.26

Biologische Quelle

human

Rekombinant

expressed in E. coli

Assay

≥80% (SDS-PAGE)

Form

frozen liquid

Mol-Gew.

~19.5 kDa

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Konzentration

1000 μg/mL

Farbe

clear colorless

NCBI-Hinterlegungsnummer

NM_003743

UniProt-Hinterlegungsnummer

Q15788

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... NCOA1(8648)

Biochem./physiol. Wirkung

Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 has been shown to be over expressed in some cancers. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptorsand have been previously used in assays detecting ligand-dependent receptor-cofactor interactions. This protein contains the Tobacco Etch virus (TEV) protease site and can be cleaved using acTEV to yield untagged SRC1 RID. This protein will be useful for assays where a native untagged protein is desired.

Physikalische Form

Clear and colorless frozen liquid solution

Angaben zur Herstellung

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Toshihiko Yanase et al.
Internal medicine (Tokyo, Japan), 43(5), 368-373 (2004-06-23)
Coregulators are a group of proteins, which modulate the nuclear receptor transactivation function. In this study, a new "coregulator disease" concept was proposed from observations of a case of androgen insensitivity syndrome (AIS) and cases involving Rubinstein-Taybi syndrome and X-linked
S A Oñate et al.
Science (New York, N.Y.), 270(5240), 1354-1357 (1995-11-24)
A yeast two-hybrid system was used to identify a protein that interacts with and enhances the human progesterone receptor (hPR) transcriptional activity without altering the basal activity of the promoter. Because the protein stimulated transactivation of all the steroid receptors
D M Heery et al.
Nature, 387(6634), 733-736 (1997-06-12)
The binding of lipophilic hormones, retinoids and vitamins to members of the nuclear-receptor superfamily modifies the DNA-binding and transcriptional properties of these receptors, resulting in the activation or repression of target genes. Ligand binding induces conformational changes in nuclear receptors

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