SML2888

LH1306

≥95% (HPLC)

• Synonym(e): 2,2’-Dimethyl-3,3’-bis[2-methoxy-3-(2-acetamidoethylamino)-methylpyridin-6-yl-oxymethyl]-1,1’-biphenyl, LH 1306, LH-1306, N,N′-(2,2′-(6,6′-(2,2′-Dimethylbiphenyl-3,3′-diyl)bis(methylene)bis(oxy)bis(2-methoxypyridine-6,3-diyl))bis(methylene)bis(azanediyl)bis(ethane-2,1-diyl))diacetamide
• Empirische Formel (Hill-System): C₃₈H₄₈N₆O₆
• CAS-Nummer: 2182653-84-3
• Molekulargewicht: 684.82
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Versandbedingung: wet ice
• Lagertemp.: -10 to -25°C

Beschreibung

Biochem./physiol. Wirkung

LH1306 is a potent programmed cell death-1/programmed death-ligand 1 (PD-1 (CD279, PDCD1)/PD-L1 (B7-H1, PDCD1-L1)) protein-protein interaction (PPI) inhibitor (IC50 = 25 nM by HTRF assay) that induces symmetrically arranged PD-L1 homodimer formation by targeting PD-L1 at the PD-1 binding site. LH1306 effectively blocks cell surface PD-1/PD-L1 interaction between PD-1-expressing Jurkat cells and co-cultured PD-L1-expressing U2OS cells (SHP-1 recruitment IC50 = 334 nM) or co-cultured PD-L1-expressing aAPC/CHO-K1 cells (NFAT signaling restoration EC50 = 4.21 μM).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable