SAB1411646

Anti-CER1 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• Synonym(e): DAND4, MGC119894, MGC119895, MGC96951
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 30.1 kDa
• Speziesreaktivität: human, mouse
• Methode(n): western blot: 1 μg/mL
• NCBI-Hinterlegungsnummer: BC069491
• UniProt-Hinterlegungsnummer: O95813
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CER1(9350)

Beschreibung

Allgemeine Beschreibung

This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. (provided by RefSeq)

Immunogen

CER1 (AAH69491.1, 1 a.a. ~ 267 a.a) full-length human protein.

Sequence
MHLLLFQLLVLLPLGKTTRHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAVPHLVGTSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA

Biochem./physiol. Wirkung

Cerberus 1 (CER1) is associated with the regulation of various pathways including nodal, Wnt, or BMP signaling pathways. During bone development, it acts as an inhibitor of BMPs (bone morphogenetic proteins). Polymorphisms in CER1 has link with osteoporosis, on bone mineral density (BMD) and bone markers in osteoporotic women. It has been reported that CER1 has been identified as a potential marker for bone mineral density and bone markers in osteoporotic women.

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable