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C221

Carboxy-PTIO potassium salt

synthetic (organic), ≥98% (TLC), NO scavenger, powder

Synonym(e):

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt, 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt

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PackungsgrößeSKUVerfügbarkeitPreis
10 mg
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CHF 227.00

Über diesen Artikel

Empirische Formel (Hill-System):
C14H16KN2O4
CAS-Nummer:
148819-94-7
Molekulargewicht:
315.39
UNSPSC Code:
12352200
PubChem Substance ID:
24892474
NACRES:
NA.32
MDL number:
MFCD00216153

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Produktname

Carboxy-PTIO potassium salt,

biological source

synthetic (organic)

Quality Level

100

assay

≥98% (TLC)

form

powder

mp

>270 °C

solubility

H2O: 100 mg/mL, DMSO: soluble (lit.)(lit.), methanol: soluble (lit.)(lit.)

storage temp.

2-8°C

SMILES string

[K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C

InChI

1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1

InChI key

VYEUQMVIGXFZQU-UHFFFAOYSA-M

General description

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO) is mainly considered as a scavenger of nitric oxide (NO).

Application

Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)

Biochem/physiol Actions

Carboxy-PTIO can make a quick reaction with nitric oxide (NO) to produce nitrogen dioxide (NO2). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.
Reacts with nitric oxide to form carboxy-PTI derivatives which in turn inhibits nitric oxide synthase.

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Dieser Artikel
217386P4154H8759
Carboxy-PTIO potassium salt

Sigma-Aldrich

C221

Carboxy-PTIO potassium salt

Carboxy-PTIO, Sodium Salt Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.

Sigma-Aldrich

217386

Carboxy-PTIO, Sodium Salt

Polyinosinic acid potassium salt Homopolymer

Sigma-Aldrich

P4154

Polyinosinic acid potassium salt

4-Hydroxy-3-methoxyphenylglycol sulfate potassium salt ≥98% (HPLC), powder

Sigma-Aldrich

H8759

4-Hydroxy-3-methoxyphenylglycol sulfate potassium salt

assay

≥98% (TLC)

assay

≥97% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

biological source

synthetic (organic)

biological source

-

biological source

synthetic (organic)

biological source

-

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

form

powder

form

solid

form

lyophilized powder

form

powder

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

H2O: 100 mg/mL, methanol: soluble (lit.)(lit.), DMSO: soluble (lit.)(lit.)

solubility

HEPES Buffer: 0.4 mg/mL

solubility

water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow

solubility

H2O: 50 mg/mL

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000538263
0000538263
MKDB6274
MKDB1944
MKCX2402

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Megumi Hada et al.
International journal of molecular sciences, 20(18) (2019-09-07)
Previously, we investigated the dose response for chromosomal aberration (CA) for exposures corresponding to less than one particle traversal per cell nucleus by high energy and charge (HZE) particles, and showed that the dose responses for simple exchanges for human
Anton Misak et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-27)
Doxycycline (DOXY) is an antibiotic routinely prescribed in human and veterinary medicine for antibacterial treatment, but it has also numerous side effects that include oxidative stress, inflammation, cancer or hypoxia-induced injury. Endogenously produced hydrogen sulfide (H₂S) and polysulfides affect similar
Xinyi Zhu et al.
Applied and environmental microbiology, 85(3) (2018-11-28)
While both iron and nitric oxide (NO) are redox-active environmental signals shown to regulate biofilm development, their interaction and roles in regulating biofilms have not been fully elucidated. In this study, exposure of Pseudomonas aeruginosa biofilms to exogenous NO inhibited
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Global Trade Item Number

SKUGTIN
C221-10MG04061833475379

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