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Merck

B3805

Sigma-Aldrich

Anti-Bone Morphogenetic Protein 5 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(e):

Anti-BMP-5

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About This Item

MDL-Nummer:
UNSPSC-Code:
51111800
NACRES:
NA.41

Biologische Quelle

goat

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

lyophilized powder

Speziesreaktivität

human

Methode(n)

immunohistochemistry (frozen sections): 5-15 μg/mL
neutralization: suitable
western blot: 0.1 μg/mL

UniProt-Hinterlegungsnummer

Anwendung(en)

research pathology

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... BMP5(653)

Immunogen

recombinant human BMP-5, expressed in NSO cells.

Biochem./physiol. Wirkung

Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. BMP5 is required for the development and fine tuning of the skeletal morphology.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Steven Pregizer et al.
Cytokine & growth factor reviews, 20(5-6), 509-515 (2009-11-11)
Much evidence suggests that "developmental regulator" genes, like those encoding transcription factors and signaling molecules, are typically controlled by many modular, tissue-specific cis-regulatory elements that function during embryogenesis. These elements are often far from gene coding regions and promoters. Bone
Elina V García et al.
Theriogenology, 81(8), 1032-1041 (2014-03-04)
Bone morphogenetic proteins (BMPs) play a crucial role in mammalian reproduction, but little is known about their expression and function in the oviduct, where preimplantation events take place. In the present study, messenger RNA (mRNA) expression of BMPs was examined
Kohei Miyazono et al.
Cytokine & growth factor reviews, 16(3), 251-263 (2005-05-06)
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various

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