373277

Hh Signaling Antagonist XI, MRT-14

The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Synonym(e): Hh Signaling Antagonist XI, MRT-14
• Empirische Formel (Hill-System): C₂₄H₂₃N₃O₆
• CAS-Nummer: 1192928-04-3
• Molekulargewicht: 449.46
• MDL-Nummer: MFCD32671861
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: DMSO: 100 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• SMILES String: O=C(NC(NC1=CC(NC(C2=CC=CC=C2)=O)=CC=C1)=O)C3=CC(OC)=C(C(OC)=C3)OC

Beschreibung

Allgemeine Beschreibung

A cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC₅₀ = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC₅₀ = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 & 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC₅₀ = 0.13 and 0.62 µM, respectively).

A cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC₅₀ = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC₅₀ = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 and 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC₅₀ = 0.13 and 0.62 µM, respectively).

The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Manetti, F., et al. 2010. Mol. Pharmacol.78, 658.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable