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Merck

CYP11B1

cytochrome P450, family 11, subfamily B, polypeptide 1

Synonyme:
CPN1, CYP11B, FHI, P450C11
Spezies:
Human CYP11B1 (1584), Mouse Cyp11b1 (110115), Rat Cyp11b1 (500892), sheep CYP11B1 (767576), cow CYP11B1 (282422), domestic guinea pig Cyp11b1 (100135511)
UniProtKB-ID:
P15538, Q14095, Q4VAQ8, Q4VAQ9, Q9UML2
Gen-ID:
  • Human(1584) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(110115) cytochrome P450, family 11, subfamily b, polypeptide 1
  • Rat(500892) cytochrome P450, family 11, subfamily b, polypeptide 1
  • sheep(767576) cytochrome P450, family 11, subfamily B, polypeptide 1
  • cow(282422) cytochrome P450, subfamily XI B, polypeptide 1
  • domestic guinea pig(100135511) cytochrome P450, family 11, subfamily b, polypeptide 1

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
ZRB2564
Anti-CYP11B1 Antibody, clone 1J14 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human, monkey
Anwendung
affinity binding assay
immunofluorescence
immunohistochemistry
western blot
HPA056348
Anti-CYP11B1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
MAB6020
Anti-Cytochrome P450 11β-Hydroxylase Antibody, clone 11B2-1A4, culture supernatant, clone 11B2-1A4, Chemicon®,
Speziesreaktivität
rat
Anwendung
immunohistochemistry
western blot
SAB1303151
ANTI-CYP11B1 (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
flow cytometry
immunohistochemistry
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
35485
2,4′-DDD, PESTANAL®, analytical standard,
Spezies
human
1445007
Mitotan, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
44012
1-(2-Chlorphenyl)-1-(4-chlorphenyl)-2,2-dichlorethan, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland,
Spezies
human
K1003
Ketoconazol, 99.0-101.0% (EP, titration),
Spezies
mouse, human, rat
UC280
Ketoconazol, ,
Spezies
mouse, human, rat

esiRNA

Produktnummer
Beschreibung
Spezies
EHU140441
MISSION® esiRNA, targeting human CYP11B1,
Spezies
human