- Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT.
Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2009-05-19)
Makoto Shirakawa, Tetsuya Yamamto, Kei Nakai, Kenichi Aburai, Sho Kawatobi, Takao Tsurubuchi, Yohei Yamamoto, Yuusaku Yokoyama, Hiroaki Okuno, Akira Matsumura
PMID19446462
ABSTRACT
We aimed at securing sufficient concentrations of (10)B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron component liposome. It consisted of three different kinds of amino acid derivatives and two fatty acids, and could react directly with the peptide synthesized first on resin by Fmoc solid-phase synthesis. In this study, lipid analog conjugated with HIV-TAT peptide (domain of human immunodeficiency virus TAT protein) and boronophenylalanine (BPA) was synthesized and successfully incorporated into liposomes.
MATERIALS