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Merck

Hand rejuvenation: a review and our experience.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (2012-01-25)
Sabrina G Fabi, Mitchel P Goldman
ABSTRACT

The aged hand is characterized by cutaneous and dermal atrophy, with deep intermetacarpal spaces, prominent bones and tendons, and bulging reticular veins. Epidermal changes include solar lentigines, seborrheic keratoses, actinic keratoses, skin laxity, rhytides, tactile roughness, and telangiectasia. A Medline search was performed on hand rejuvenation from 1989 to 2011, and results are summarized. Practical applications of these procedures are also discussed. Reports of injectable hyaluronic acid, calcium hydroxylapatite, poly-L-lactic acid, autologous fat transfer, vein treatment, and chemical peels, along with lasers and light sources such as Q-switched laser, intense pulsed light, photodynamic therapy, nonablative resurfacing lasers, and ablative resurfacing lasers, in the rejuvenation of hands were found. Review of the literature revealed options for minimally invasive treatment for rejuvenation of the skin and volume restoration of the dorsal hand. These treatments include injectables and fat transfer for volume restoration; sclerotherapy or vein ablation for dorsal hand vein treatment; and chemical peels, lasers, light, and energies for the treatment of epidermal and dermal changes.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Brij® L23 solution, 30 % (w/v) in H2O
Sigma-Aldrich
Decaethylene glycol mono­dodecyl ether, nonionic surfactant
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Thesit®, for membrane research
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ECO BRIJ® L4, average Mn ~362
Sigma-Aldrich
ECO Brij® L23
Sigma-Aldrich
Brij® L23, main component: tricosaethylene glycol dodecyl ether
Sigma-Aldrich
Brij® L4, average Mn ~362
Sigma-Aldrich
Brij® L23, suitable for Stein-Moore chromatography