Skip to Content
Merck

Acute encephalopathy associated with influenza A virus infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2003-02-21)
Christoph Steininger, Theresia Popow-Kraupp, Hermann Laferl, Andreas Seiser, Irene Gödl, Schiva Djamshidian, Elisabeth Puchhammer-Stöckl
ABSTRACT

Twenty-one patients aged 4-78 years with influenza A virus-associated acute encephalopathy were studied. Influenza A virus could be detected only in a cerebrospinal fluid (CSF) specimen obtained from 1 of 18 patients, despite the use of a highly sensitive polymerase chain reaction assay. Six patients experienced influenzal encephalopathy during the course of respiratory illness. Five of these patients had hypoprothrombinemia and 4 had increased serum creatinine levels, indicating hepatic and/or renal dysfunction. Fourteen patients experienced postinfluenzal encephalopathy <or=3 weeks after resolution of acute respiratory symptoms. In 6 patients, focal areas of high signal intensity were visible on T2-weighted magnetic resonance images of the brain. Adenovirus DNA was detected in CSF specimens obtained from 4 (36%) of 11 patients with postinfluenzal encephalopathy. Thus, influenzal encephalopathy is frequently associated with metabolic disorders, whereas postinfluenzal encephalopathy appears to have different possible etiologies.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-Influenza A Antibody, H-3 Antigen, clone 30-2F11-F7-A5, clone 30-2F11-F7-A5, Chemicon®, from mouse
Pricing and availability is not currently available.
Sigma-Aldrich
Anti-Influenza A Antibody, H-1 Antigen, clone 58AB7-19-18, clone 58AB7-19-18, Chemicon®, from mouse
Pricing and availability is not currently available.