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USP

Torsemide

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C16H20N4O3S
CAS Number:
56211-40-6
Molecular Weight:
348.42
MDL number:
MFCD00866166
UNSPSC Code:
41116107
PubChem Substance ID:
329751356
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

torsemide

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

InChI

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

InChI key

NGBFQHCMQULJNZ-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Torsemide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
  • Torsemide Tablets
  • Torsemide Compounded Oral Suspension

Biochem/physiol Actions

Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H319,H361fd

Hazard Classifications

Eye Irrit. 2 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J S Blose et al.
The Annals of pharmacotherapy, 29(4), 396-402 (1995-04-01)
To review the clinical pharmacology of torsemide and to compare it with currently available loop diuretics, particularly furosemide. An English-language MEDLINE search, 1985 to October 1994, was used to identify pertinent literature, including review articles. Data from scientific literature were
S F Fowler et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 52(16), 1771-1780 (1995-08-15)
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of torsemide are reviewed. Torsemide belongs to the pyridine-sulfonylurea class of loop diuretics. Its primary site of activity is the thick ascending limb of the loop of Henle, where
James J DiNicolantonio
Future cardiology, 8(5), 707-728 (2012-09-28)
Furosemide is the most widely prescribed loop diuretic in the setting of systolic heart failure (HF), yet torsemide has been shown to have less inter- and intra-individual variation in bioavailability and a longer duration of action compared with furosemide. Thus
Loop diuretics: comparison of torsemide, furosemide, and bumetanide.
B P Chen
Connecticut medicine, 60(6), 343-345 (1996-06-01)

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