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  • A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization.

A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization.

The Journal of biological chemistry (2002-10-03)
Desiree van der Kleij, Eicke Latz, Jos F H M Brouwers, Yvonne C M Kruize, Marion Schmitz, Evelyn A Kurt-Jones, Terje Espevik, Esther C de Jong, Martien L Kapsenberg, Douglas T Golenbock, Aloysius G M Tielens, Maria Yazdanbakhsh
RÉSUMÉ

Schistosome infections are characterized by prominent T cell hyporesponsiveness during the chronic stage of infection. We found that schistosome-specific phosphatidylserine (PS) activated TLR2 and affected dendritic cells such that mature dendritic cells gained the ability to induce the development of IL-10-producing regulatory T cells. Using mass spectrometry, schistosomal lysophosphatidylserine (lyso-PS) was identified as the TLR2-activating molecule. This activity appears to be a unique property of schistosomal lyso-PS, containing specific acyl chains, because neither a synthetic lyso-PS (16:0) nor PS isolated from the mammalian host activates TLR2. Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology.

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Sigma-Aldrich
Phospholipase C from Bacillus cereus, ≥200 units/mg protein