Z3777

ZD7288 hydrate

≥98% (HPLC)

• Synonyme(s) : 4-(N-Ethyl-N-phenylamino)-1,2 dimethyl-6-(methylamino) pyrimidinium chloride, ICI-D7288, N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine hydrochloride, ZD 7288
• Formule empirique (notation de Hill): C₁₅H₂₀N₄ · HCl · xH₂O
• Poids moléculaire : 292.81 (anhydrous basis)
• Numéro MDL: MFCD16879001
• Code UNSPSC : 12352200
• ID de substance PubChem : 329831610
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: DMSO: 10 mg/mL, clear
• Auteur: AstraZeneca
• Température de stockage: 2-8°C
• Chaîne SMILES: O.Cl.CCN(c1ccccc1)C2=CC(=N/C)\N(C)C(C)=N2
• InChI: 1S/C15H20N4.ClH.H2O/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;;/h6-11H,5H2,1-4H3;1H;1H2/b16-14+;;
• Clé InChI: NCEDDDWQLCMZQG-UPONXUSQSA-N

Description

Application

ZD7288 hydrate has been used as I_h blocker to study its effect on
neocortical tissue. It has been used as hyperpolarization-activated and cyclic nucleotide-gated (HCN)-channel blocker to test the involvement of HCN channels in the phototransduction pathway.

Actions biochimiques/physiologiques

Selective blocker of cation channel Ih; If blocker and sino-atrial node function modulator, blocks hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels.

ZD7288 can block hippocampal synaptic plasticity.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable