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Key Documents

SRP4145

Sigma-Aldrich

IL-6 from rat

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

Synonyme(s) :

B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, IFN-b2, MGI-2

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About This Item

Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

rat

Produit recombinant

expressed in E. coli

Pureté

≥90% (HPLC)
≥90% (SDS-PAGE)

Forme

lyophilized

Puissance

<0.01 ng/mL ED50

Poids mol.

~21.7 kDa

Conditionnement

pkg of 10 μg

Impuretés

endotoxin, tested

Numéro d'accès NCBI

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

rat ... Il6(24498)

Description générale

Interleukin- 6 (IL-6) is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It is a pro-inflammatory cytokine. IL-6 originates from mononuclear phagocytes, T and B lymphocytes, vascular endothelial cells and fibroblasts. It has a role in various physiological and pathological processes. IL-6 plays an important role in intracellular signaling pathways. Recombinant rat IL-6 is a 21.7kDa protein containing 187 amino acid residues.

Forme physique

Lyophilized without any additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 10 mM HCl to a concentration of 0.1-1.0 μg/μL. The solution can then be diluted into other aqueous buffers.

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Yongpan Huang et al.
BMC complementary medicine and therapies, 23(1), 2-2 (2023-01-04)
The necessity of increasing the efficiency of organ preservation has encouraged researchers to explore the mechanisms underlying diabetes-related myocardial injuries. This study intended to evaluate the protective effects of oxymatrine (OMT) in myocardial injury caused by type 2 diabetes mellitus.
Targeting interlukin-6 to relieve immunosuppression in tumor microenvironment.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine (2017)
Meta-analysis of the role of IL-6 rs1800795 polymorphism in the susceptibility to prostate cancer: Evidence based on 17 studies.
Liu TZ
Medicine (2017)
Lorena M Amaral et al.
American journal of obstetrics and gynecology, 211(2), 158-158 (2014-02-20)
Preeclampsia is a multisystem disorder recognized as hypertension with proteinuria developing >20 weeks' gestation. Preeclampsia is associated with chronic immune activation characterized by increased T and B lymphocytes, cytokines, and antibodies activating the angiotensin II type I receptor (AT1-AA). Hypertension
Elin Banke et al.
Metabolism: clinical and experimental, 63(6), 831-840 (2014-04-02)
The bacteria Staphylococcus aureus is part of the normal bacterial flora and produces a repertoire of enterotoxins which can cause food poisoning and toxic shock and might contribute to the pathogenesis of inflammatory diseases. These enterotoxins directly cross-link the T

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