SML3272

Chroman 1

≥98% (HPLC)

• Synonyme(s) : (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide, (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide, (S)-Chroman 1
• Formule empirique (notation de Hill): C₂₄H₂₈N₄O₄
• Numéro CAS: 1273579-40-0
• Poids moléculaire : 436.50
• Numéro MDL: MFCD23098792
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C

Description

Actions biochimiques/physiologiques

Highly potent and ROCK2-selective Rho kinase (ROCK1/2) inhibitor that is superior to Y-27632 in improving the viability of hPSCs in cultures.

Chroman 1 is a highly potent and ROCK2-selective Rho kinase inhibitor (ROCK1/2 IC50 = 52/1 pM) with much greater potency and selectivity than Y-27632 (ROCK1/2 IC50 = 71/46 nM). Chroman 1 is superior to Y-27632 in improving the viability of hPSCs in cultures (50 nM Chroman 1 is equivalent to 10 µM Y-27632; hESCs WA09 in E8 medium on vitronectin-coated plate). The combination of chroman 1, emricasan, polyamines (40 ng/ml putrescine, 4.5 ng/ml spermidine, and 8 ng/ml spermine), and trans-ISRIB (CEPT) is reported to enhance the survival of genetically stable hPSCs by simultaneously blocking several stress mechanisms that otherwise compromise cell structure and function.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable