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Key Documents

SAB4501301

Sigma-Aldrich

Anti-NMDAR1 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

GLURZ1, GRIN1, Glutamate [NMDA] receptor subunit ζ 1 precursor, N-methyl-D-aspartate receptor, NMD-R1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 105 kDa

Espèces réactives

mouse, human, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q05586

Numéro d'accès UniProt

Q05586

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... GRIN1(2902)

Description générale

N-methyl-d-aspartate receptor (NMDAR1) is a subtype of the ionotropic glutamate receptors (iGluRs). It is coded by GRIN1 gene. It is located on human chromosome 9q34.3. NMDAR1is expressed in epidermal melanocytes.
Anti-NMDAR1 antibody detects endogenous levels of total NMDAR1 protein.

Immunogène

The antiserum was produced against synthesized peptide derived from human NMDAR1.

Immunogen Range: 856-905

Application

Anti-NMDAR1, C-Terminal antibody has been used in western blot analysis.

Actions biochimiques/physiologiques

N-methyl-d-aspartate receptor (NMDAR1) plays an important role in the pathophysiology of schizophrenia, bipolar disorder and depression. Mutations in GRIN1 gene results in severe intellectual disability, hypotonia, hyperkinetic and stereotyped movements, and epilepsy.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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The effect of the NMDA receptor-dependent signaling pathway on cell morphology and melanosome transfer in melanocytes
Ni J, et al.
Journal of Dermatological Science, 84(3), 296-304 (2016)
The activation of N-methyl-d-aspartate receptors downregulates transient outward potassium and L-type calcium currents in rat models of depression
Liu X, et al.
American Journal of Physiology. Cell Physiology, 313(2), C187-C196 (2017)
De novo GRIN1 mutations: An emerging cause of severe early infantile encephalopathy
Zehavi Y, et al.
European Journal of Medical Genetics, 60(6), 317-320 (2017)
Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder
Mundo E, et al.
Molecular Psychiatry, 8(2), 241-241 (2003)
Xin Liu et al.
American journal of physiology. Cell physiology, 313(2), C187-C196 (2017-06-02)
Major depression is an important clinical factor in ventricular arrhythmia. Patients diagnosed with major depression overexpress N-methyl-d-aspartate receptors (NMDARs). Previous studies found that chronic NMDAR activation increases susceptibility to ventricular arrhythmias. We aimed to explore the mechanisms by which NMDAR
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