P8982

Anti-phospho-p53 (pSer³⁹²) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• Numéro MDL: MFCD02097164
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous glycerol solution
• Poids mol.: antigen 53 kDa
• Espèces réactives: mouse, human
• Technique(s): microarray: suitable; western blot (chemiluminescent): 1:1,000 using p53 fusion proteins with CKII phosphorylation or an extract of hydroxyurea-treated MvILu cells
• Numéro d'accès UniProt: P04637
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... TP53(7157) ; mouse ... Trp53(22059)

Description

Description générale

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

Spécificité

Does not react with non-phosphorylated p53.

Immunogène

synthetic peptide corresponding to residues around Ser³⁹² of human p53 conjugated to KLH.

Actions biochimiques/physiologiques

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

Forme physique

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol

Notes préparatoires

Purified using protein A and peptide affinity chromatography.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable