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M1255

Sigma-Aldrich

Calcein Blue

Powder

Synonyme(s) :

4-Methylumbelliferone-8-methyliminodiacetic acid

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About This Item

Formule empirique (notation de Hill):
C15H15NO7
Numéro CAS:
54375-47-2
Poids moléculaire :
321.28
Numéro CE :
259-129-8
Numéro MDL:
MFCD00006867
Code UNSPSC :
12171500
ID de substance PubChem :
24896629
Nomenclature NACRES :
NA.47

product name

Calcein Blue, fluorescent dye

Forme

powder

Couleur

white to light yellow

Solubilité

1 M NaOH: 50 mg/mL

Fluorescence

λex 322 nm; λem 445 nm in methanol

Adéquation

suitable for indicator for EDTA titration

Application(s)

diagnostic assay manufacturing
hematology
histology

Température de stockage

room temp

Chaîne SMILES 

CC1=CC(=O)Oc2c(CN(CC(O)=O)CC(O)=O)c(O)ccc12

InChI

1S/C15H15NO7/c1-8-4-14(22)23-15-9(8)2-3-11(17)10(15)5-16(6-12(18)19)7-13(20)21/h2-4,17H,5-7H2,1H3,(H,18,19)(H,20,21)

Clé InChI

RJPSHDMGSVVHFA-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Calcein Blue is a cell-permeable dye that stains viable cells. Upon entering the cell, intracellular esterases cleave the acetoxymethyl (AM) ester group, yielding the membrane-impermeable Calcein Blue fluorescent dye. The staining applications of Calcein blue include tumor tissues, mineralized tissues, bone, amino acids, and many more.

Application

Calcein blue has been used fluorescent labeling of the mineralised sections of bone. Calcein blue AM ester hydrolyzed to calcein blue is suitable as a a viability stain, both microscopically, and in fluorescence activated cell sorting systems. It is also used as a merker of living cells like Schwann cells at neuromuscular junctions.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Liangbo Hu et al.
Virologica Sinica, 34(4), 454-466 (2019-06-16)
Baculovirus can transduce a wide range of mammalian cells and is considered a promising gene therapy vector. However, the low transduction efficiency of baculovirus into many mammalian cells limits its practical application. Co-expressing heterologous viral glycoproteins (GPs), such as vesicular
Xiaomian Wu et al.
International journal of nanomedicine, 7, 1215-1225 (2012-03-16)
Compared with titanium (Ti) and other metal implant materials, poly(ether-ether ketone) (PEEK) shows outstanding biomechanical properties. A number of studies have also reported attractive bioactivity for nano-TiO(2) (n-TiO(2)). In this study, n-TiO(2)/PEEK nanocomposites were prepared, taking advantage of the unique
Carolyn J Loveridge et al.
Scientific reports, 7(1), 13241-13241 (2017-10-19)
Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed an unexpected phenotype of spinal protrusion in
Maintained larval growth in mussel larvae exposed to acidified under-saturated seawater.
Ventura A
Scientific Reports, 6, 23728-23728 (2016)
Na-Ryum Bin et al.
Journal of immunology (Baltimore, Md. : 1950), 201(2), 700-713 (2018-06-10)
In the immune system, degranulation/exocytosis from lymphocytes is crucial for life through facilitating eradication of infected and malignant cells. Dysfunction of the NK cell exocytosis process has been implicated with devastating immune diseases, such as familial hemophagocytic lymphohistiocytosis, yet the
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