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L9170

Sigma-Aldrich

Lipodisq®

Styrene: Maleic Anhydride Copolymer 3:1, Pre-hydrolyzed, powder, from synthetic

Synonyme(s) :

Lipid nanoparticle, Liposomal delivery system

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.26

Source biologique

synthetic

Pureté

98-100%

Forme

powder

Poids mol.

9500 Da

Conditions de stockage

(Keep container tightly closed in a dry and well-ventilated place
Keep in a dry place)

Température de stockage

room temp

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Description générale

Research area: Cell Structure

Lipodisq® polymers contain styrene and maleic acid monomer units. This product is the pre-hydrolyzed form of the SMA polymer, with styrene and maleic acid monomers. These polymer-lipid complexes are mainly generated by detergent-free methods.

Functional pH range: 6.0 - 9.0

Application

Lipodisq® reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. In general, Lipodisq polymers are potentially useful in mitigating the use of detergents for the solubilization of membrane proteins. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.

Informations légales

Lipodisq is a registered trademark of Malvern Cosmeceutics Limited

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

427845

Polypropylene-graft-maleic anhydride, viscosity 425 cPs

416320

Poly(methyl vinyl ether-alt-maleic anhydride), average Mw ~1,080,000, average Mn ~311,000

416339

Poly(methyl vinyl ether-alt-maleic anhydride), average Mw ~216,000, average Mn ~80,000

188050

Poly(ethylene-alt-maleic anhydride), average Mw 100,000-500,000, powder

434558

Poly(4-styrenesulfonic acid-co-maleic acid) sodium salt, average Mw ~20,000, powder

531278

Poly(isobutylene-alt-maleic anhydride), average Mw ~6,000, 12-200 mesh (85%)

531367

Poly[(isobutylene-alt-maleic acid, ammonium salt)-co-(isobutylene-alt-maleic anhydride)], average Mw ~60,000

460060

Polyisoprene-graft-maleic anhydride, average Mw ~25,000

662631

Poly(styrene-alt-maleic acid) sodium salt solution, 13 wt. % in H2O

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Indra D Sahu et al.
Biochemistry, 52(38), 6627-6632 (2013-08-30)
Pulsed EPR DEER structural studies of membrane proteins in a lipid bilayer have often been hindered by difficulties in extracting accurate distances when compared to those of globular proteins. In this study, we employed a combination of three recently developed
Juan F Bada Juarez et al.
Chemistry and physics of lipids, 222, 51-58 (2019-05-19)
Lipodisq™ nanoparticles have been used to extract surface lipids from the cuticle of two strains (wild type, N2 and the bacteria-resistant strain, agmo-1) of the C. elegans nematode without loss of viability. The extracted lipids were characterized by thin layer
Maria Lyngaas Torgersen et al.
Journal of biomedical nanotechnology, 16(4), 419-431 (2020-09-25)
Many promising pharmaceutically active compounds have low solubility in aqueous environments and their encapsulation into efficient drug delivery vehicles is crucial to increase their bioavailability. Lipodisq nanoparticles are approximately 10 nm in diameter and consist of a circular phospholipid bilayer
Detergent-Free Formation and Physicochemical Characterization of Nanosized Lipid-Polymer Complexes: Lipodisq
Orwick MC, et al.
Angewandte Chemie (International ed. in English), 51(19), 4653-4657 (2012)
Masafumi Tanaka et al.
Chemistry and physics of lipids, 232, 104954-104954 (2020-08-23)
Lipid emulsions are potential carriers for poorly water-soluble drugs. Previously, we revealed that lipid nanoparticles complexed with styrene maleic acid copolymer (SMA) disintegrate under acidic pH. In the present study, SMA-containing lipid emulsions (SMA emulsions) were prepared and their physicochemical
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