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H7039

Sigma-Aldrich

3-Hydroxy-3-methylglutaryl-CoA reductase human

solution

Synonyme(s) :

HMGCoA Reductase, HMGR

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About This Item

Numéro de classification (Commission des enzymes):
1.1.1.34 (BRENDA, IUBMB)
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Pureté

≥90% (SDS-PAGE)

Niveau de qualité

200

Forme

solution

Activité spécifique

2-8 units/mg protein

Poids mol.

~76 kDa (for the fusion protein)

Numéro d'accès UniProt

P04035

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... HMGCR(3156)

Application

3-Hydroxy-3-methylglutaryl-CoA reductase human has been used:
  • in anti-HMGCR enzyme linked immunosorbent assay (ELISA)
  • as an antigen to measure anti-HMGCR antibodies by blot analysis
  • in HMG-CoA reductase activity assays
  • as an antigen to compare in-house antigen via sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)/western blot

Actions biochimiques/physiologiques

3-Hydroxy-3-methylglutaryl-CoA reductase/HMGCR serves as a rate limiting enzyme in mevalonate pathway. It also controls the oncogenic Hippo transducers TAZ/YAP. HMGCR also perform as a genetic modifier for Alzheimer′s disease (AD).
Hydroxy-3-methylglutaryl-CoA reductase catalyzes the committed step in cholesterol biosynthesis.

Propriétés physiques

Consists of the HMG CoA reductase catalytic domain fused to GST protein.

Définition de l'unité

One unit will convert 1.0 μmole of NADPH to NADP+ per minute at 37 °C.

Forme physique

Supplied as a solution containing 250 μg protein in 50 mM Tris pH 7.5, with 5 mM DTT, 1:200 Protease Inhibitor Cocktail (Catalog Number P8340) and 50% (w/v) glycerol.

Inhibiteur

Réf. du produit
Description
Tarif

Substrat

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

HMG-CoAR expression in male breast cancer: relationship with hormone receptors, Hippo transducers and survival outcomes
Di BA, et al.
Scientific reports, 6, 35121-35121 (2016)
Myopathy with anti-HMGCR antibodies Perimysium and myofiber pathology
Alshehri A, et al.
Neurology? neuroimmunology & neuroinflammation, 2(4), e124-e124 (2015)
Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese
Chang XL, et al.
Oncotarget, 7(16), 22746-22751 (2016)
Marie Hudson et al.
Medicine, 95(44), e5280-e5280 (2016-11-20)
The objective of this study was to investigate the frequency of autoantibodies to hydroxymethylglutaryl coenzyme A reductase (HMGCR) in systemic sclerosis (SSc) and associations with inflammatory myositis and statin exposure.This was a cross-sectional, multicenter study of 306 subjects from the
ChemVassa: a new method for identifying small molecule hits in drug discovery
Moldover B, et al.
The Open Medicinal Chemistry Journal, 6, 29-29 (2012)
Afficher tous les articles scientifiques apparentés

Articles

Cholesterol Biosynthesis

Cholesterol biosynthesis starts in the hepatic endoplasmic reticulum with acetyl-CoA, yielding 3-hydroxy-3-methylglutaryl-CoA via HMG-CoA synthase.

Cholesterol Biosynthesis

Cholesterol biosynthesis starts in the hepatic endoplasmic reticulum with acetyl-CoA, yielding 3-hydroxy-3-methylglutaryl-CoA via HMG-CoA synthase.

Cholesterol Biosynthesis

Cholesterol biosynthesis starts in the hepatic endoplasmic reticulum with acetyl-CoA, yielding 3-hydroxy-3-methylglutaryl-CoA via HMG-CoA synthase.

Cholesterol Biosynthesis

Cholesterol biosynthesis starts in the hepatic endoplasmic reticulum with acetyl-CoA, yielding 3-hydroxy-3-methylglutaryl-CoA via HMG-CoA synthase.

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