D4007

5,5-Diphenylhydantoin

≥98%

• Synonyme(s) : 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin
• Formule empirique (notation de Hill): C₁₅H₁₂N₂O₂
• Numéro CAS: 57-41-0
• Poids moléculaire : 252.27
• Numéro Beilstein : 384532
• Numéro CE : 200-328-6
• Numéro MDL: MFCD00005264
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278370
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98%
• Forme: powder
• Pf: 293-295 °C (lit.)
• Solubilité: DMSO: soluble
• Chaîne SMILES: O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
• Clé InChI: CXOFVDLJLONNDW-UHFFFAOYSA-N
• Informations sur le gène: human ... CNR1(1268) , CNR2(1269) , CYP2C9(1559) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Faah(29347) , Scn1a(81574) , Scnn1g(24768) , Slc6a1(79212)

Description

Description générale

5,5-Diphenylhydantoin is an anticonvulsant, which is used to treat tonic-clonic seizures, complex partial seizures and neurosurgical related seizures. It induces osteoblast proliferation and differentiation. 5,5-Diphenylhydantoin used to treat epilepsy. It reduces the hyperexcitability of tissues and may be associated with cerebellar atrophy.

Application

5,5-Diphenylhydantoin has been used for phenytoin treatment. It has also been used to slow down or prevent mesoendoderm cell migration.

Actions biochimiques/physiologiques

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na⁺, K⁺, and Ca²⁺ channels.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H351,H360FD
• Conseils de prudence: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classification des risques: Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges