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C9992

Sigma-Aldrich

Anti-Caveolin-2 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution, suitable for western blot: 1 μg/mL

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About This Item

Numéro MDL:
MFCD01633098
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~20 kDa

Espèces réactives

pig (predicted), mouse, rat, canine, human (predicted)

Concentration

~1 mg/mL

Technique(s)

indirect immunofluorescence: suitable
western blot: 1-2 μg/mL using whole extract of mouse 3T3-L1 adipocytes or rat kidney NRK cells

Numéro d'accès UniProt

P51636

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CAV2(858)
mouse ... Cav2(12390)
rat ... Cav2(363425)

Description générale

Caveolin-2 is an isoform of caveolin, an integral transmembrane protein of the caveolae membranes. It has a molar mass of 20-22 kDa and is a major coat protein found in caveolae of most cell types. It exists as two isoforms α and β due to alternative splicing of the respective mRNAs. Caveolin-2α corresponds to the full-length protein (20 kDa, 162 amino acids), whereas caveolin-2β isoform lacks a 13 amino acid sequence at its N-terminus.

Immunogène

synthetic peptide corresponding to amino acids 1-20 located at the N-terminus of mouse caveolin-2, conjugated to KLH. This sequece is identical in rat caveolin-2, highly conserved (90% identity) in human, dog, and pig caveolin-2, and is not found in caveolin-1 and caveolin-3.

Actions biochimiques/physiologiques

Caveolin-2 colocalizes and forms a hetero-oligomeric complex with caveolin-1 in vivo. Caveolins family members function as scaffolding proteins to organize and concentrate specific lipids such as cholesterol and glycosylphosphatidylinositol (GPI) and lipid modified signaling molecules within caveolae membranes. Caveolin-2 is phosphorylated on Ser23 and Ser36 and modulates caveolin-1-dependent caveola formation.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Romina Paula Bulacio et al.
Journal of cellular biochemistry, 120(4), 4966-4974 (2018-10-01)
Caveolin-2 (Cav-2) is expressed in a variety of cell tissue, and it has also been found in renal tissue. The expression of Cav-2 in proximal tubules is still unclear. The aim of this study was to carry out a complete
P E Scherer et al.
The Journal of biological chemistry, 272(46), 29337-29346 (1997-11-20)
Caveolae are microdomains of the plasma membrane that have been implicated in organizing and compartmentalizing signal transducing molecules. Caveolin, a 21-24-kDa integral membrane protein, is a principal structural component of caveolae membrane in vivo. Recently, we and other laboratories have
R G Anderson
Annual review of biochemistry, 67, 199-225 (1998-10-06)
The cell biology of caveolae is a rapidly growing area of biomedical research. Caveolae are known primarily for their ability to transport molecules across endothelial cells, but modern cellular techniques have dramatically extended our view of caveolae. They form a
S Li et al.
The Journal of biological chemistry, 271(1), 568-573 (1996-01-05)
Caveolin, a 22-24-kDa integral membrane protein, is a principal component of caveolar membranes in vivo. Caveolin has been proposed to function as a scaffolding protein to organize and concentrate signaling molecules within caveolae. Because of its unusual membrane topology, both
M Sargiacomo et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(20), 9407-9411 (1995-09-26)
A 22-kDa protein, caveolin, is localized to the cytoplasmic surface of plasma membrane specializations called caveolae. We have proposed that caveolin may function as a scaffolding protein to organize and concentrate signaling molecules within caveolae. Here, we show that caveolin
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