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A1755

Sigma-Aldrich

Aminophylline dihydrochloride hyderate

≥98%, powder

Synonyme(s) :

(Theophylline)2 · Ethylenediamine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1), Theophylline hemiethylenediamine complex

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About This Item

Formule empirique (notation de Hill):
C7H8N4O2 · 0.5C2H8N2
Numéro CAS:
317-34-0
Poids moléculaire :
210.21
Numéro CE :
206-264-5
Numéro MDL:
MFCD00013221
Code UNSPSC :
41106305
ID de substance PubChem :
24277691
Nomenclature NACRES :
NA.77

Pureté

≥98%

Forme

powder

Couleur

white to off-white

Solubilité

H2O: 50 mg/mL (solutions should be freshly prepared.)
alcohol: insoluble

Température de stockage

−20°C

Chaîne SMILES 

NCCN.CN1C(=O)N(C)c2nc[nH]c2C1=O.CN3C(=O)N(C)c4nc[nH]c4C3=O

InChI

1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2

Clé InChI

FQPFAHBPWDRTLU-UHFFFAOYSA-N

Informations sur le gène

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

Application

Aminophylline has been used:
  • as a positive control in the selective inhibitor of nuclear export, KPT-350 zebrafish dosing experiments
  • as a positive control for the determination of the spasmolytic activity of C. aeruginosa extracts
  • as a phosphodiesterase (PDE) inhibitor in inhibitor studies to quantify its potency to inhibit PDE4A1A and PDE3A enzyme in an assay

Actions biochimiques/physiologiques

Aminophylline is a methylxanthine compound containing theophylline andethylenediamine in a ratio of 2:1. It acts as a bronchodilator and is used to treat chronic lung diseases like asthma, bronchitis, or emphysema.
Non-selective phosphodiesterase (PDE) inhibitor. Antiepileptic drug

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Danieli Barino Salinas et al.
Pediatric research, 87(1), 137-145 (2019-07-26)
There is a need to prognosticate the severity of cystic fibrosis (CF) detected by newborn screening (NBS) by early assessment of CF transmembrane conductance regulator (CFTR) protein function. We introduce novel instrumentation and protocol for evaluating CFTR activity as reflected
Antiasthmatic effect of Curcuma aeruginosa extract on isolated organ of the trachea
Marliana E, et al.
F1000Research (2018)
O J Wagner et al.
Surgical endoscopy, 26(10), 2961-2968 (2012-05-15)
Within the next few years, the medical industry will launch increasingly affordable three-dimensional (3D) vision systems for the operating room (OR). This study aimed to evaluate the effect of two-dimensional (2D) and 3D visualization on surgical skills and task performance.
D Mokra et al.
Advances in experimental medicine and biology, 756, 341-347 (2012-07-28)
As inflammation plays an important role in the pathogenesis of neonatal meconium aspiration syndrome (MAS), anti-inflammatory agents including inhibitors of phosphodiesterases (PDE) are increasingly used in the treatment. To evaluate side effects of PDE inhibitors, this study analyzed changes in
Nicole M Bhave et al.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 14, 89-89 (2013-01-01)
Adenosine cardiovascular magnetic resonance (CMR) can accurately quantify myocardial perfusion reserve. While regadenoson is increasingly employed due to ease of use, imaging protocols have not been standardized. We sought to determine the optimal regadenoson CMR protocol for quantifying myocardial perfusion
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