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91C

Sigma-Aldrich

Leukocyte Naphthol AS-D Chloroacetate (Specific Esterase) Kit

Synonyme(s) :

Leder Stain

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About This Item

Code UNSPSC :
12352106
Nomenclature NACRES :
NA.47

Description

Kit formulated with all liquid reagents

Niveau de qualité

500

Durée de conservation

Expiry date on the label.

IVD

for in vitro diagnostic use

Application(s)

hematology
histology

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Application

Esterases are ubiquitous in nature and encompass a series of different enzymes acting upon select substrates. With the 91C kit, Naphthol AS-D Chloroacetate is enzymatically hydrolyzed by "specific esterase, " liberating a free naphthol compound. This then couples with a diazonium compound, forming highly colored deposits at sites of enzyme activity. This enzyme is usually considered specific for cells of granulocytic lineage. May be used to detect neutrophils in peripheral blood, bone marrow or tissue sections which have been paraffin embedded.

Composants de kit également disponibles séparément

Réf. du produit
Description
FDS
  • 915Citrate Solution, pH 3.6±0.1 (25 °C), 27 mM 50 mLFDS
  • 912Fast Red Violet LB Base Solution 10 mLFDS
  • 911Naphthol AS-D Chloroacetate Solution 10 mLFDS
  • 911Naphthol AS-D Chloroacetate Solution 50 mLFDS

Pictogrammes

Health hazardCorrosionExclamation mark
GHS08,GHS05,GHS07

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1 - Skin Sens. 1 - STOT RE 2 Oral - STOT SE 3

Organes cibles

Kidney, Respiratory system

Risques supp

EUH019

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Ganesan Ramesh et al.
Kidney international, 65(2), 490-499 (2004-01-14)
Salicylate was recently shown to provide protection against cisplatin nephrotoxicity in rats. We have demonstrated that enhanced tumor necrosis factor-alpha (TNF-alpha) production mediates, in part, cisplatin nephrotoxicity. The purpose of this study was to determine if the protective effects of
Ralf A Linker et al.
Journal of immunology (Baltimore, Md. : 1950), 180(4), 2204-2213 (2008-02-06)
The neurotrophic cytokines ciliary neurotrophic factor and leukemia inhibitory factor (LIF) play a key role in neuronal and oligodendrocyte survival and as protective factors in neuroinflammation. To further elucidate the potential of endogenous LIF in modulating neuroinflammation, we studied myelin
Paramahamsa Maturu et al.
Translational oncology, 7(4), 484-492 (2014-06-28)
The role of inflammation in cancer has been reported in various adult malignant neoplasms. By contrast, its role in pediatric tumors has not been as well studied. In this study, we have identified and characterized the infiltration of various inflammatory
Tarek M El-Achkar et al.
American journal of physiology. Renal physiology, 295(2), F534-F544 (2008-05-23)
Tamm-Horsfall protein (THP) is a glycoprotein with unclear functions expressed exclusively in thick ascending limbs (TAL) of the kidney. Its role in ischemic acute kidney injury is uncertain, with previous data suggesting a possible negative effect by enhancing cast formation
Vittoria Esposito et al.
American journal of physiology. Renal physiology, 304(4), F440-F450 (2012-12-14)
C/EBP homologous protein (CHOP) is an important mediator of endoplasmic reticulum (ER) stress-induced cell and organ injury. Here we show that lipopolysaccharide (LPS)-induced acute kidney injury (AKI) is associated with ER stress and elevated CHOP. We postulated that CHOP(-/-) mice
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