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Y0001149

Berberine chloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Berberine chloride form, Natural Yellow 18

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About This Item

Formule empirique (notation de Hill):
C20H18ClNO4
Numéro CAS:
633-65-8
Poids moléculaire :
371.81
Numéro C.I. (Colour Index):
75160
Numéro Beilstein :
3836585
Numéro MDL:
MFCD00011939
Code UNSPSC :
41116107
ID de substance PubChem :
329830786
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

berberine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

COC1=C(C=[N+](CCC2=C3C=C4C(OCO4)=C2)C3=C5)C5=CC=C1OC.[Cl-]

InChI

1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

Clé InChI

VKJGBAJNNALVAV-UHFFFAOYSA-M

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Fluorescent stain for heparin in mast cells

Actions biochimiques/physiologiques

An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Effects of berberine on amelioration of hyperglycemia and oxidative stress in high glucose and high fat diet-induced diabetic hamsters in vivo.
Liu C, Wang Z, Song Y, et al.
BioMed Research International, 2015, 313808-313808 (2015)
Victor P Bagla et al.
BMC complementary and alternative medicine, 14, 383-383 (2014-10-09)
Different parts of Podocarpus henkelii have been used in many cultures around the world to treat ailments such as cholera, stomach diseases, rheumatism, cancer, canine distemper in dogs and gall sickness in cattle. The aim of this study was to
Mohamed A Dkhil et al.
Parasitology research, 114(4), 1581-1593 (2015-02-11)
Plant-based natural products are promising sources for identifying novel agents with potential anti-Eimeria activity. This study explores possible effects of berberine on Eimeria papillata infections in the jejunum of male Swiss albino mice. Berberine chloride, when daily administered to mice
Mousa O Germoush et al.
Journal of cancer research and clinical oncology, 140(7), 1103-1109 (2014-04-20)
The present study was designed to investigate the possible protective effects of berberine against cyclophosphamide (CP)-induced hepatotoxicity in rats. The experimental rats were treated with berberine orally at a dose of 50 mg/kg for 11 consecutive days after the administration
Hany K M Dweck et al.
Current biology : CB, 30(1), 17-30 (2019-12-17)
Taste systems detect a vast diversity of toxins, which are perceived as bitter. When a species adapts to a new environment, its taste system must adapt to detect new death threats. We deleted each of six commonly expressed bitter gustatory receptors (Grs)
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