PHR1772

Méropénème trihydraté

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonyme(s) : Acide (1R,5S,6S)-2-[(3S,5S)-5-(diméthylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyéthyl]-1-méthylcarbapén-2-èm-3-carboxylique trihydraté
• Formule empirique (notation de Hill): C₁₇H₂₅N₃O₅S · 3H₂O
• Numéro CAS: 119478-56-7
• Poids moléculaire : 437.51
• Numéro MDL: MFCD08600005
• Code UNSPSC : 41116107
• ID de substance PubChem : 329823603
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material; pharmaceutical secondary standard
• Niveau de qualité: 300
• Agence: traceable to Ph. Eur. Y0001252; traceable to USP 1392454
• Famille d'API: meropenem
• CofA (certificat d'analyse): current certificate can be downloaded
• Conditionnement: pkg of 500 mg
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Température de stockage: 2-8°C
• Chaîne SMILES: O.O.O.C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N2C1=O)C(O)=O
• InChI: 1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1
• Clé InChI: CTUAQTBUVLKNDJ-OBZXMJSBSA-N

Description

Description générale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Meropenem belongs to the class of a semi-synthetic 1β-methylcarbapenem antibiotics. It shows an extremely broad-spectrum of antibacterial performance and is known for its high stability against renal dehydropeptidase-I (DHP-I).

Application

Lincomycin Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and peritoneal dialysis solution by spectrophotometric and various chromatography techniques.(58)

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Actions biochimiques/physiologiques

Le méropénème trihydraté est une bêta-lactamine à spectre ultra large présentant une activité antibiotique contre les bactéries à Gram positif et à Gram négatif.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAB7853 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H317,H334
• Conseils de prudence: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Classification des risques: Resp. Sens. 1 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable