SCC186

DOV13 Human Ovarian Carcinoma Cell Line

The DOV13 human ovarian carcinoma cell line is a highly characterized model for metastatic ovarian cancer studies.

• Code UNSPSC : 41106514
• Nomenclature NACRES : NA.28

Propriétés

• Application(s): cell analysis

Description

Description générale

The DOV13 human ovarian carcinoma cell line is one of the most studied and characterized cellular models for metastatic ovarian cancers, having been utilized in many cellular studies focusing on cellular migration and invasion. DOV13 cells are responsive to vascular endothelial growth factor (VEGF) (2), express estrogen receptor (3) and matrilysin (MMP-7), a marker of metastatic and invasive epithelial carcinomas (4), and secrete the proteolytic factor matrix metalloproteinase-2 (MMP-2) (5). DOV13 cells are genetically well-characterized and harbor deletion of the tumor suppressor CDKN2A (6). The characteristics of the DOV13 cell line make it a pertinent model for the most malignant ovarian cancer.

Epithelial carcinomas are the most common ovarian cancer, accounting for 90 percent of cases. Ovarian carcinoma is typically diagnosed at late stage after cancer has metastasized beyond the ovaries, greatly reducing treatment options and contributing to the poor survival rate of this cancer type (1). Robust cellular models have been essential to understanding the mechanisms of ovarian cancer metastasis and development of potential therapeutic strategies.

Source:
The DOV13 human ovarian carcinoma cell line was isolated from ovarian adenocarcinoma tissue (2).

Research Category:
Cancer

Origine de la lignée cellulaire

Human, Cancer Cells

Conditionnement

≥1X10⁶ cells/vial

Stockage et stabilité

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Autres remarques

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

Clause de non-responsabilité

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable