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Merck
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Key Documents

71610-M

Millipore

D-Desthiobiotin

Synonyme(s) :

5-methyl-2-oxo-4-imidazolidinehexanoic acid, 5-methyl-2-oxo-4-imidazoline-caproic acid, 6-(5-methyl-2-oxo-imidazolidin-4-yl)hexanoic acid, Dethiobiotin

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About This Item

Code UNSPSC :
41106500
Nomenclature NACRES :
NA.56

Forme

solid

Fabricant/nom de marque

Novagen®

Conditions de stockage

OK to freeze

Température de stockage

2-8°C

Catégories apparentées

Description générale

D-Desthiobiotin provides a gentle elution of Strep•Tag II proteins from the biotin-binding site of Strep•Tactin resins. The D-Desthiobiotin is offered as a lyophilized powder for preparation of elution buffer.

Application

D-Desthiobiotin has been used to elute recombinant strap-tag proteins bound to Strep-Tactin superflow high capacity resin.

Actions biochimiques/physiologiques

D-Desthiobiotin is an analog of biotin. It is a non-sulfur metabolite and a biotin precursor. It displays lower binding towards biotin-binding proteins when compared to biotin.

Composants

•: 1 g: D-Desthiobiotin

Avertissement

Toxicity: Standard Handling (A)

Informations légales

NOVAGEN is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Philip A Band et al.
Protein expression and purification, 71(1), 62-73 (2010-01-05)
Work from multiple laboratories has clarified how the structural domains of botulinum neurotoxin A (BoNT/A) disable neuronal exocytosis, but important questions remain unanswered. Because BoNT/A intoxication disables its own uptake, light chain (LC) does not accumulate in neurons at detectable
Jessica Marcandalli et al.
Cell, 176(6), 1420-1431 (2019-03-09)
Respiratory syncytial virus (RSV) is a worldwide public health concern for which no vaccine is available. Elucidation of the prefusion structure of the RSV F glycoprotein and its identification as the main target of neutralizing antibodies have provided new opportunities
James D Hirsch et al.
Analytical biochemistry, 308(2), 343-357 (2002-11-07)
The high-affinity binding of biotin to avidin, streptavidin, and related proteins has been exploited for decades. However, a disadvantage of the biotin/biotin-binding protein interaction is that it is essentially irreversible under physiological conditions. Desthiobiotin is a biotin analogue that binds
Nadia Martinez-Martin et al.
Cell, 174(5), 1158-1171 (2018-07-31)
Characterizing cell surface receptors mediating viral infection is critical for understanding viral tropism and developing antiviral therapies. Nevertheless, due to challenges associated with detecting protein interactions on the cell surface, the host receptors of many human pathogens remain unknown. Here

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