551600-M

Quercetin, Dihydrate

A cell-permeable and reversible inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A2 (IC₅₀ = 2 µM).

• Synonyme(s) : Quercetin, Dihydrate, 3,3ʹ,4ʹ,5,7-Pentahydroxyflavone
• Formule empirique (notation de Hill): C₁₅H₁₀O₇ · 2H₂O
• Numéro CAS: 6151-25-3
• Poids moléculaire : 338.27
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: >95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: acetic acid: 1 mg/mL; aqueous base: 1 mg/mL; DMSO: 5 mg/mL
• Température de stockage: 10-30°C
• InChI: 1S/C15H10O7.2H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;;/h1-5,16-19,21H;2*1H2
• Clé InChI: GMGIWEZSKCNYSW-UHFFFAOYSA-N

Description

Description générale

A cell-permeable and reversible inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A₂ (IC₅₀ = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.

A cell-permeable inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A₂ (IC₅₀ = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.

Actions biochimiques/physiologiques

Primary Target
PI 3-kinase

Target IC₅₀: 43 nM, 3.8 µM, 2 µM against PIM1 kinase, PI 3-K, and phospholipase A2, respectively

Avertissement

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Autres remarques

Bullock, A.N., et al. 2005. J. Med. Chem.48, 7604.
Howitz, K.T., et al. 2003. Nature425, 191.
Wei, Y.Q., et al. 1994. Cancer Res.54, 4952.
Shibasaki, F., et al. 1993. Biochem. J.289, 227.
Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm.186, 624.
Levy, J., et al. 1984. Biochem. Biophys. Res. Commun.123, 1227.
Graziani, Y., et al. 1983. Eur. J. Biochem.135, 583.
Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
Ruckstuhl, M., et al. 1979. Biochem. Pharmacol.28, 535.
Beretz, A., et al. 1978. Experientia 34, 1054.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1