516566

PPARγ Antagonist III, G3335

The PPARγ Antagonist III, G3335, also referenced under CAS 36099-95-3, controls the biological activity of PPARγ.

• Synonyme(s) : PPARγ Antagonist III, G3335, H-Trp-Glu-OH
• Formule empirique (notation de Hill): C₁₆H₁₉N₃O₅
• Numéro CAS: 36099-95-3
• Poids moléculaire : 333.34
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: water: 30 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1
• Clé InChI: PWIQCLSQVQBOQV-AAEUAGOBSA-N

Description

Description générale

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (K_D = ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀ = 31.9 µM) in transfected COS-7 cells.

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (K_D ~8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀ = 31.9 µM) in transfected COS-7 cells.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
PPARγ

Product does not compete with ATP.

Reversible: yes

kd = ~ 8 µM as PPARγ antagonist

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Notes préparatoires

Addition of a small amount of acid or base may be required for complete solubilization.

Reconstitution

Following reconstitution aliquot freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Ye, F., et al. 2006. Chembiochem7, 74.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable