5.04776

Cytochalasin D, Zygosporium mansonii

InSolution, ≥98%, 10 mM in DMSO, A cell-permeable fungal toxin

• Synonyme(s) : InSolution Cytochalasin D, Zygosporium mansonii, Lygosporin A, Zygosporin A, NSC 209835
• Formule empirique (notation de Hill): C₃₀H₃₇NO₆
• Numéro CAS: 22144-77-0
• Poids moléculaire : 507.62
• Numéro MDL: MFCD00077706
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (TLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Température de stockage: −70°C
• InChI: 1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
• Clé InChI: SDZRWUKZFQQKKV-JHADDHBZSA-N

Description

Description générale

A cell-permeable fungal toxin that is approximately 10 times more potent than cytochalasin B (>Cat. No. 250233) in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments at 10 µM. Inactivates low conductance K⁺ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca²⁺ levels. Cytochalasin D also exhibits antibiotic and anti-tumor properties.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
microfilaments

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Forme physique

A 10 mM (1 mg/197 µL) sterile-filtered solution of Cytochalasin D, Zygosporium mansonii (Cat. No. 250255) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Autres remarques

Sasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA92, 2026.
Blankson, H., et al. 1995. Exp. Cell Res.218, 522.
Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun.209, 1102.
Verschueren, H., et al. 1995. Eur. J. Cell Biol.66, 335.
Aszalos, A., et al. 1994. Cell Immunol. 157, 81.

Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.

Betina, V., and Micekova, D. 1972. Chem. Abstr.77, 160508q.
Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 188.6 °F - (refers to pure substance)
• Point d'éclair (°C): 87 °C - (refers to pure substance)