4995

Ouabain octahydrate

≥95% (HPLC), solid, Na⁺,K⁺-ATPase inhibitor, Calbiochem^®

• Synonyme(s) : Ouabain, Octahydrate, Strophanthin G
• Formule empirique (notation de Hill): C₂₉H₄₄O₁₂ · 8H₂O
• Numéro CAS: 11018-89-6
• Poids moléculaire : 728.77
• Numéro MDL: MFCD00149240
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: Ouabain, Octahydrate, Inhibits Na⁺,K⁺-ATPase.
• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white to off-white
• Solubilité: hot water: 10 mg/mL; room-temperature water: insoluble
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C29H44O12.8H2O/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31;;;;;;;;/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3;8*1H2/t13?,15-,16+,17?,18+,19+,21+,22?,23?,24?,25?,26?,27?,28?,29?;;;;;;;;/m0......../s1
• Clé InChI: TYBARJRCFHUHSN-HMNHGHQSSA-N

Description

Description générale

Inhibits Na⁺ and K⁺-dependent ATPases. Has cardiotonic properties.

Inhibits Na⁺,K⁺-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G₂ delay.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Na⁺,K⁺-ATPase

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
Hasenauer, J., et al. 1993. J. Biol. Chem.268, 3289.
Rakowski, F.F. 1993. J. Gen. Physiol.101, 117.
Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry31, 2025.
Xu, Z.J., et al. 1992. J. Physiol.456, 405.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H300,H331,H373
• Conseils de prudence: P260 - P264 - P271 - P301 + P310 - P304 + P340 + P311 - P314
• Classification des risques: Acute Tox. 1 Oral - Acute Tox. 3 Inhalation - STOT RE 2
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3