480001

NDSB-195

A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins.

• Synonyme(s) : NDSB-195, Dimethylethylammonium Propane Sulfonate
• Formule empirique (notation de Hill): C₇H₁₇NO₃S
• Numéro CAS: 160255-06-1
• Poids moléculaire : 195.28
• Code UNSPSC : 12611902
• Nomenclature NACRES : NA.21

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: water: soluble
• Conditions d'expédition: ambient
• Température de stockage: 15-25°C

Description

Description générale

A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. Zwitterionic over a wide pH range. Does not absorb significantly in the near-UV range. Easily removed by dialysis.

Application

• Protein stabilizer, NDSB-195, enhances the dynamics of the β4 -α2 loop of ubiquitin.: This research explores how NDSB-195 stabilizes proteins by enhancing the dynamics of the β4-α2 loop of ubiquitin, providing insights into its mechanism of action as a protein stabilizer (Wang et al., 2016).


• Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines.: The study demonstrates the effectiveness of NDSB-195 in suppressing the oligomerization of problematic compounds, showcasing its utility in biochemical and pharmaceutical applications (Mizukoshi et al., 2015).


• Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor.: This article discusses the interaction of NDSB-195 with acidic fibroblast growth factor, emphasizing its role in preventing protein aggregation during biochemical processes (Xiang et al., 2008).


• Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA-binding domain of the Ets transcription factor in complex with target DNA.: The study uses NDSB-195 in the preparation and crystallization process, enhancing the stability and quality of the DNA-binding domain crystals for X-ray diffraction analysis (Suwa et al., 2008).

Avertissement

Toxicity: Irritant (B)

Autres remarques

Goldberg, M.E., et al. 1996. Folding & Design 1, 21.
Vuillard, L., et al. 1995. Anal. Biochem. 230, 290.
Vuillard, L., et al. 1995. Biochem. J. 305, 337.
Vuillard, L., et al. 1994. FEBS Lett.353, 294.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3