475872

MnTMPyP

Cell-permeable superoxide dismutase (SOD) mimetic.

• Synonyme(s) : MnTMPyP, Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide
• Formule empirique (notation de Hill): C₇₂H₆₅MnN₈O₁₃S₄
• Poids moléculaire : 1433.53
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated; protect from light
• Couleur: black
• Solubilité: water: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

Cell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O₂^{– •} (rate constant ~4 x 10⁷ M^-1 s^-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O₂^• oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.

Actions biochimiques/physiologiques

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Izbicka, E., et al. 1999. Cancer Res.59, 639.
Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable