475838

Mifepristone

≥99% (titration), solid, progesterone and glucocorticoid receptor antagonist, Calbiochem^®

• Synonyme(s) : Mifepristone, (11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486
• Formule empirique (notation de Hill): C₂₉H₃₅NO₂
• Numéro CAS: 84371-65-3
• Poids moléculaire : 429.59
• Numéro MDL: MFCD00867226
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: Mifepristone, A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors.
• Niveau de qualité: 100
• Pureté: ≥99% (titration)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Impuretés: ≤0.1% Steroid substances
• Couleur: yellow
• Solubilité: ethanol: 10 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
• Clé InChI: VKHAHZOOUSRJNA-GCNJZUOMSA-N

Description

Description générale

A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Inhibits P-glycoprotein (P-gp) function and down-modulates P-gp mediated drug resistance. Displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Regulates the expression of Fas and FasL in mouse endometrium and TRAIL in prostate cancer cells. As an antioxidant, it offers neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.

A cell-permeable, synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Reported to inhibit P-glycoprotein (P-gp) function and down-modulate P-gp mediated drug resistance. Also displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Shown to regulate the expression of Fas and FasL in mouse endometrium and of TRAIL in prostate cancer cells. As an antioxidant, it is reported to offer neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Progesterone and glucocorticoid receptors

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

McCullers, D.L., et al. 2002. Neuroscience109, 219.
Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci.955, 159.
Gao, F., et al. 2001. Acta Pharmacol. Sin.22, 524.
Hyder, S.M., et al. 2001. Int. J. Cancer92, 469.
Lam, F.C., et al. 2001. J. Neurochem. 76, 1121.
Sridhar, S., et al. 2001. Cancer Res.61, 7179.
Behl, C., et al. 1997. Eur. J. Neurosci.9, 912.
Greb, R.R., et al. 1997. Hum. Reprod.12, 1280.
Gruol, D.J., et al. 1994. Cancer Res.54, 3088.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H360
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable