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LM4113

Avanti

25-hydroxycholesterol (D6)

Avanti Research™ - A Croda Brand

Synonyme(s) :

cholest-5-ene-3β,25-diol(d6)

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About This Item

Formule empirique (notation de Hill):
C27H40D6O2
Numéro CAS:
88247-69-2
Poids moléculaire :
408.69
Code UNSPSC :
12352100
Nomenclature NACRES :
NA.25

Forme

methanol solution

Conditionnement

pkg of 1 × 1 mL (LM4113-1EA)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand

Concentration

~10 μg/mL (Refer to C of A for lot specific concentration. )

Application(s)

lipidomics
metabolomics

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(O)(C([2H])([2H])[2H])C([2H])([2H])[2H]

Description générale

25-hydroxycholesterol is an oxygenated sterol and a hydroxylated derivative of cholesterol.

Actions biochimiques/physiologiques

25-hydroxycholesterol inhibits cholesterol biosynthesis by downregulating the function of 3-hydroxy-3-methylglutaryl-CoA reductase. It is found to be implicated in atherosclerosis. 25-hydroxycholesterol levels are known to be increased in hypercholesterolemic condition.

Conditionnement

2 mL Amber Glass Sealed Ampule (LM4113-1EA)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Christopher M Adams et al.
The Journal of biological chemistry, 279(50), 52772-52780 (2004-09-29)
The current paper demonstrates that cholesterol and its hydroxylated derivative, 25-hydroxycholesterol (25-HC), inhibit cholesterol synthesis by two different mechanisms, both involving the proteins that control sterol regulatory element-binding proteins (SREBPs), membrane-bound transcription factors that activate genes encoding enzymes of lipid
Cholsoon Jang et al.
Nature medicine, 22(4), 421-426 (2016-03-08)
Epidemiological and experimental data implicate branched-chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms that underlie this link remain unclear. Insulin resistance in skeletal muscle stems from the excess accumulation of lipid species, a process that
Rosamaria Lappano et al.
PloS one, 6(1), e16631-e16631 (2011-02-10)
The hydroxylated derivatives of cholesterol, such as the oxysterols, play important roles in lipid metabolism. In particular, 25-hydroxycholesterol (25 HC) has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis. 25 HC is detectable in human
Ken Cheng et al.
Journal of agricultural and food chemistry, 66(33), 8876-8884 (2018-07-26)
Membrane lipids, including sphingolipids and glycerol-phospholipids, are essential in maintaining the skin's barrier function in mammals, but their composition in fish skin and their response to diets have not been evaluated. This study investigated the impacts of reducing dietary eicosapentaenoic

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