QBD10553

MAL-dPEG^®₁₂-TFP ester

• Synonyme(s) : Polyethylene glycol
• Formule empirique (notation de Hill): C₄₀H₆₀F₄N₂O₁₇
• Poids moléculaire : 916.90
• Numéro MDL: MFCD28505513
• Code UNSPSC : 12352108
• ID de substance PubChem : 329823942
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: >90%
• Forme: solid or viscous liquid
• Pertinence de la réaction: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• Architecture des polymères: shape: linear; functionality: heterobifunctional
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)OC2=C(C(F)=CC(F)=C2F)F

Description

Caractéristiques et avantages

MAL-dPEG^®₁₂-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG^® spacer arm and an amine-reactive active ester on the other end. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. 2,3,5,6-tetrafluorophenyl (TFP) ester ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG^® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Informations légales

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable