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D5146

Sigma-Aldrich

Diazolidinyl urea

≥95%

Synonyme(s) :

1-[1,3-Bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea, Diazolidinylurea, N-Hydroxymethyl-N-[1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-N′-hydroxymethylurea, N-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N′-bis(hydroxymethyl)urea

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About This Item

Formule empirique (notation de Hill):
C8H14N4O7
Numéro CAS:
78491-02-8
Poids moléculaire :
278.22
Numéro CE :
278-928-2
Numéro MDL:
MFCD03547942
Code UNSPSC :
12352100
ID de substance PubChem :
57654106
Nomenclature NACRES :
NA.22

Pureté

≥95%

Forme

powder

Température de stockage

2-8°C

Chaîne SMILES 

OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O

InChI

1S/C8H14N4O7/c13-1-9-7(18)10(2-14)5-6(17)12(4-16)8(19)11(5)3-15/h5,13-16H,1-4H2,(H,9,18)

Clé InChI

SOROIESOUPGGFO-UHFFFAOYSA-N

Description générale

Diazolidinyl urea is urea derivative that is commonly used as a preservative and antimicrobial agent in cosmetics and personal care products.

Application

  • Impact of cosmetic preservatives on skin cells: A study examined the effects of various cosmetic preservatives, including Diazolidinyl Urea, on healthy human skin cells, highlighting the cellular responses and potential implications for skin health (Głaz et al., 2023).
  • Formaldehyde releasers in personal care: An extensive clinical review discussed allergic contact dermatitis caused by formaldehyde and formaldehyde releasers such as Diazolidinyl Urea, providing insights into allergic reactions and safety concerns in dermatological practice (Goossens and Aerts, 2022).
  • Carcinogenic potential of cosmetic ingredients: Research on potential carcinogens in makeup cosmetics included Diazolidinyl Urea, emphasizing the safety and regulatory aspects concerning its use in cosmetic formulations (Balwierz et al., 2023).
  • Patch testing for allergen sensitivity: A study integrated Diazolidinyl Urea in a patch test series to evaluate skin sensitization and allergic reactions in patients, aiding in the assessment of its allergenic potential (Bizjak et al., 2022).

Clause de non-responsabilité

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319

Classification des risques

Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

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Claus Zachariae et al.
Contact dermatitis, 53(5), 268-277 (2005-11-15)
The elicitation potential of the cosmetic preservative diazolidinyl urea was studied in formaldehyde- and diazolidinyl urea-sensitized volunteer patients using a stepwise controlled exposure design. The test product was a facial moisturizer, preserved with varying concentrations of diazolidinyl urea, ranging from
A T Karlberg et al.
Contact dermatitis, 38(1), 20-28 (1998-03-21)
Reliable and uncomplicated methods for detection of free formaldehyde in products preserved with formaldehyde donors are desirable to decrease the risk of allergic contact dermatitis. The aim of this study was to develop a method that could be used in
The different decomposition properties of diazolidinyl urea in cosmetics and patch test materials
Doi, et al.
Contact Dermatitis, 65, 81-91 (2011)
Diazolidinyl urea: incidence of sensitivity, patterns of cross?reactivity and clinical relevance.
Hectorne KJ & Fransway AF
Contact Dermatitis, 30(1), 16-19 (1994)
S D Winslow et al.
Environmental science & technology, 35(20), 4103-4110 (2001-11-01)
Preservation of chemical analytes in drinking water samples is necessary to obtain accurate information concerning contaminant occurrence. Sample preservation to prevent biodegradation is important for most samples and analytes. With the unique demands of environmental methods, it is not always
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