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  • Synthesis, characterization and antitumour activity of metal complexes of 5-carboxy-2-thiouracil.

Synthesis, characterization and antitumour activity of metal complexes of 5-carboxy-2-thiouracil.

Metal-based drugs (2008-05-14)
U P Singh, S Singh, S M Singh
ABSTRACT

Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
5-Carboxy-2-thiouracil
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