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Key Documents

RES0114M-A7

SAFC

MES sodium salt

Pharma Manufacturing

Synonym(s):

2-(N-Morpholino)ethanesulfonic acid sodium salt, 4-Morpholineethanesulfonic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C6H12NNaO4S
CAS Number:
Molecular Weight:
217.22
Beilstein:
3765682
EC Number:
MDL number:
UNSPSC Code:
12161700
NACRES:
NA.21

biological source

synthetic

Quality Level

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

Endotoxin and microbial, tested

useful pH range

5.5-6.7

pKa 

6.1

suitability

suitable for manufacturing use

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES string

[Na+].[O-]S(=O)(=O)CCN1CCOCC1

InChI

1S/C6H13NO4S.Na/c8-12(9,10)6-3-7-1-4-11-5-2-7;/h1-6H2,(H,8,9,10);/q;+1/p-1

InChI key

IRHWMYKYLWNHTL-UHFFFAOYSA-M

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General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step.

Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Application

MES Sodium is a biological buffer often referred to as a “Good′s” buffer. The pKa of MES is 5.96 which makes MES an ideal candidate for cell culture media and protein based buffer formulations to maintain a stable environment in solution. MES Sodium is considered to be non-toxic to culture cell lines, highly water soluble and provides high-solution clarity.

MES Sodium is used in cell culture media, biopharmaceutical buffer formulations both upstream and downstream and diagnostic reagents. MES based buffers are used in purification bioprocesses of antibodies, peptides, proteins and blood components.

Packaging

Product is available in the following package sizes:
RES0114M-A701X: 100g container
RES0114M-A702X 1kg container
RES0114M-A704X: 10kg container
RES0114M-A705X: 25kg container

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

replaced by

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Takamitsu Miyafusa et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 64(Pt 6), 512-515 (2008-06-10)
Capsular polysaccharides (CPs) are important virulence factors of Staphylococcus aureus. The biosynthesis of type 5 and type 8 CPs (CP5 and CP8), which are produced by most clinical isolates of S. aureus, is catalyzed by 16 CP-assembling proteins. One of
Yue Yuan et al.
Biochemistry, 50(34), 7350-7360 (2011-08-03)
This study is aimed at investigating the molecular basis of environmental adaptation of woolly mammoth hemoglobin (Hb) to the harsh thermal conditions of the Pleistocene ice ages. To this end, we have carried out a comparative biochemical-biophysical characterization of the
Lars Haag et al.
The EMBO journal, 21(17), 4402-4410 (2002-08-29)
In the icosahedral (T = 4) Semliki Forest virus, the envelope protomers, i.e. E1-E2 heterodimers, make one-to-one interactions with capsid proteins below the viral lipid bilayer, transverse the membrane and form an external glycoprotein shell with projections. The shell is
Theresa E Bankston et al.
Journal of chromatography. A, 1217(14), 2123-2131 (2010-03-03)
Hydroxyapatite (HAP) columns, widely used for chromatographic separation of proteins and other biomolecules because of their unique selectivity and ability to resolve complex mixtures, exhibit limited stability at acidic conditions requiring careful control of pH. Even with buffered solutions, however
Ekta G Ahuja et al.
Acta crystallographica. Section D, Biological crystallography, 60(Pt 6), 1129-1131 (2004-05-26)
Phenazines are broad-spectrum antibiotic metabolites produced by organisms such as Pseudomonas and Streptomyces. Phenazines have been shown to enhance microbial competitiveness and the pathogenic potential of the organisms that synthesize them. PhzA (163 residues, approximate molecular weight 18.7 kDa) is

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