218728
Caspase-9 Inhibitor III
The Caspase-9 Inhibitor III, also referenced under CAS 403848-57-7, controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
Caspase-9 Inhibitor III, Ac-LEHD-CMK
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About This Item
Empirical Formula (Hill Notation):
C24H35ClN6O9
CAS Number:
Molecular Weight:
587.02
UNSPSC Code:
12352200
NACRES:
NA.54
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Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
white
solubility
water: 1 mg/mL
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Reported to reduce myocardial infarct size during reperfusion (~70 nM).
A potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (~70 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-9
caspase-9
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against caspase-9
Warning
Toxicity: Standard Handling (A)
Sequence
Ac-Leu-Glu-His-Asp-CMK
Other Notes
Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Hazel Stewart et al.
iScience, 26(11), 108080-108080 (2023-10-20)
The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has been confirmed independently by ribosome profiling.
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