12668-M
Albumin, Human Serum, Fraction V
Synonym(s):
Albumin, Human Serum, Fraction V
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About This Item
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Assay
≥95% (SDS-PAGE)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
water: 20 mg/mL
storage temp.
2-8°C
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
General description
Human serum albumin (HSA), a globular, soluble, and unglycosylated monomeric protein, is the most abundant protein in the plasma. It is a multidomain protein consisting of three homologous domains, named I, II, and III. Each of these domains contains subdomains A and B possessing common structural motifs. The HSA gene is present on the human chromosome location 4q13.3.
Biochem/physiol Actions
Human serum albumin (HSA) serves as a carrier protein for fatty acids, thyroid hormones, and steroids. It plays a critical role in stabilizing extracellular fluid volume. HSA acts as an excipient for vaccines and therapeutic protein drugs. It is also used as a cell culture medium supplement to produce vaccines and pharmaceuticals. HSA is used to treat hemodialysis, acute liver failure, chronic liver disease. HSA has importance in biological applications, such as ligand trapping, nano delivery of drugs, and fusion proteins.
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Gabriella Fanali et al.
Molecular aspects of medicine, 33(3), 209-290 (2012-01-11)
Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-domain macromolecule, representing the main determinant of plasma oncotic pressure and the main modulator of fluid distribution between body compartments. HSA displays an extraordinary ligand binding capacity
Angelica M Merlot et al.
Frontiers in physiology, 5, 299-299 (2014-08-28)
Serum albumin is a multi-functional protein that is able to bind and transport numerous endogenous and exogenous compounds. The development of albumin drug carriers is gaining increasing importance in the targeted delivery of cancer therapy, particularly as a result of
Yang He et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(47), 19078-19083 (2011-11-02)
Human serum albumin (HSA) is widely used in clinical and cell culture applications. Conventional production of HSA from human blood is limited by the availability of blood donation and the high risk of viral transmission from donors. Here, we report
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